A Molecular Dynamic Model of Tryptophan Overproduction in Escherichia coli

Several deterministic models simulate the main molecular biology interactions among numerous mechanisms controlling dynamics of tryptophan operon in native strains. However, no exist to investigate bacterial production from a biotechnological point view. Here, we modified for propose working model that incorporates activity secretion systems and genetic modifications made two reported E. coli The resultant could emulate same order magnitude as those quantified experimentally by genetically engineered strains GPT1001 GPT1002 shake flasks. We hope this work may contribute rational development biological define include parameters components designing engineering efficient chassis produce valuable chemicals.